Sep 10


GHRP-6 Reviewed

The GHRP-6 consists of 6 amino acids.  The hexapeptide plays a special role by telling the body to secrete hGH while simultaneously blocking out somatostatin, a hormone known to stop the release entirely.

What is an Amino Acid?

Amino acids are organic compounds that combine and form proteins.   The two are considered the building blocks of life.  The short polymer chains formed by amino acids and proteins are called peptides with the longer chains being called either polypeptides or proteins.  Polymers are linear.  They are unbranched.  Each amino acid within the chain is attached to two nearby amino acids.

Translation is the process of making proteins.  The step-by-step addition of amino acids to a growing protein chain is called a ribosome.  Amino acids are added in an order which is read through the genetic code from an mRNA template.  It is a RNA copy of an organism’s genes.

A body needs amino acids to do many things.  For example, amino acids help with the digestion process by breaking down food.  They’re essential for growth and repair body tissue.  Amino acids have long been regarded as one of the most important compounds in the body for good reason.

Amino acids perform additional body functions and can be classified into three groups.  They are essential amino acids, nonessential amino acids, and conditional amino acids.  Here is how they differ:

  • Essential amino acids cannot be made by the body.  They come from food sources and there are nine different types.  They are histidine, isoleucine, leucine, lysine, methionine, phenylanlanine, threonine, trypotophan, and valine.
  • Nonessential amino acids.  They are produced by the body and include alanine, asparagine, aspartic acid, and glutamic acid.
  • Conditional amino acids.  Not needed except in times of illness and high stress.  They include arginine, cysteine, glutamine, tyrosine, glycine, ornithine, proline, and serine.

What Makes Amino Acids Important

There are a number of things that make amino acids important.  For example, some of the key elements of amino acid are carbon, hydrogen, oxygen, and nitrogen.  Amino acids are very important to neurotransmitter transport and biosynthesis.

Amino acids play a critical role within the body.  This is particularly true about proteinogenic and non-proteinogenic amino acids.  Excitatory and inhibitory neurotransmitters are affected in the brain.

Other amino acids synthesize porphyrins found in red blood cells.  They also affect the non-standard carnitine which is used in lipid transport.  Certain amino acids are needed for different age groups and medical conditions.  They also differ between species which can affect research.

Benefits of GHRP-6

There are definite advantages to testing GHRP-6 for research purposes.  The benefits of the peptide include:

  • Its ability to lower body fat.
  • Its ability to increase muscle.
  • Its ability to increase strength.
  • Its ability to grow bone tissue
  • Its ability to improve strength.
  • Its ability to improve muscular endurance.
  • Its ability to increase stamina.
  • Its anti-inflammatory properties.

Hexapeptides like GHRP are among a group that mimics natural growth releasers.  There are natural and synthetic forms with each having its own list of properties.

Some of the different versions of peptides include:

  • GHRP-1
  • GHRP-2
  • GHRP-6

13GHRP-6 has served its use by being a template to create other peptides.  The amino acids have tetra penta and pseudotripepide properties.  The synthetics do not respond to pituitary or hypothalamic glands the way that natural substances do.  This is primarily because of the different structure homology they possess.  Their receptors do not respond the same way.

Cloning the original hormone has allowed researchers to produce the best artificial version of the hormone available.  Synthetic GHRP-6 does not have the same homology as the natural receptors.

The chemical design of manufactured GHRP6 has been studied on:

  • Free Fatty Acids
  • Neurotransmitters
  • rHGH
  • Glucocorticoids
  • Exogenous Somaostatin

Understanding the chemical base of GHRP can make it easier to make better, more precise chemicals for future studies.

Fat Burning and Muscle Building

GHRP-6 can help burn fat and build muscle over time.  It makes the liver work on IGF-1 hormone secretion.  GHRP-6 releases hormones in different dosages which isn’t well-known.  It is different than GHRH, however, because it tends to be more efficient on research test subjects.  It works synergistically.

When GHRP-6 and insulin are used simultaneously, GH response to GHRP-6 is increased.  Carbohydrates and dietary fats consumed around the administration window of GH secretagogues blunt the GH release.

Studies in normal mice showed the following differences when introduced to GHRP-6:

  • Boy Composition
  • Muscle Growth
  • Memory Function
  • Cardiac Function
  • Glucose Metabolism

Continued research will allow scientists to gain more insight on the effects of GHRP-6 on test subjects.  GH secretagogues differ between endogenous or exogenous GH.  The former contains 5 isoforms of hormone and the latter contains only 20 kilodalton isoform.  Different isoforms affect tissue in subtle ways.  A pulse-like release of GH from the pituitary is cleared within hours of the GH secretagogues being administered.  It does not necessarily raise plasma IGF1 levels.

The subject of many studies, GHRP-6’s effectiveness largely depends on two things- time and dosage.  It can work naturally on the pituitary and hypothalamic sites of research test subjects.  This is due in part to the hormone release brought forth by GHRP-6.  It was inhibited by somatostatin which targets the hypothalamus.

GHRP-6 brought GRF neurons to life therefore inhibiting somatostatin.  Unlike GHRP-2, GHRP-6 doesn’t affect cAMP levels in cells.  Proof is evident that it does have the power to activate growth hormone release from somatotrophs.  This is done through different receptors of unknown mechanisms.

Each research test subject respond to the hormones differently according to their physical condition.  Obesity can affect hormone secretion making it lower.  GHRP-6 can be independent of gender and age depending on dosage even without noadregenic paths playing a role in a2 adrenegic receptors.

Intresting Video: Aquaporin Academic Version


Reference links used to create this research:



Article Name
GHRP-6 is an hgH secretagogue which naturally increases the amount of hgH in the body. It increases lean body mass and reduces fat.